YANG Shuo,YANG Min.Study of Preparation Technology of The Granules of Complex Prescription Antialcoholismic[J].HEILONGJIANG AGRICULTURAL SCIENCES,2016,(08):101-104.[doi:10.11942/j.issn1002-2767.2016.08.0101]
复方解酒颗粒剂的制备工艺研究
- Title:
- Study of Preparation Technology of The Granules of Complex Prescription Antialcoholismic
- 文章编号:
- 1002-2767（2016）08-0101-04
- 分类号:
- R283.6；TQ460.6
- 文献标志码:
- A
- 摘要:
- 为了研究复方解酒颗粒剂（葛花和人参）的最佳制备工艺。考察原料药浸膏与不同填充剂的配比、润湿剂（乙醇）的浓度、干燥的温度对颗粒剂外观性状、粒度、水分、溶化性的影响，并筛选出最佳工艺。结果表明：原料药与填充剂（浸膏∶蔗糖粉∶糊精）按1∶3∶1的比例，乙醇浓度85%，干燥温度80 ℃，制得的颗粒成型性高、溶解度好。
- Abstract:
- In order to study the compound granules therapy (flower of kudzuvine and ginseng) the best preparation technology. API extract and different ratio of filling agent, wetting agent (ethanol) concentration, the temperature of the drying of granules in character, the influence of particle size, moisture content, melting, and select the best process. The results showed that active pharmaceutical ingredients and filler (extract∶sugar powder∶dextrin) according to the proportion of 1∶3∶1, ethanol concentration of 85%, the drying temperature 80 ℃, high formability of particles and good solubility.
参考文献/References:
[1]
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北京：中国医药科技出版社，
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[2]国家中医药管理局《中华草本》编委会.中华草本[M].上海:上海科技出版社，1999. [3]张启华,王卫华，岳松珍.加味葛花解醒汤对实验性肝损伤的防护作用[J].中医药研究，1998,14（2）：30-32. [4]戴雨霖.葛花人参解酒护肝机制的研究[D].长春：长春中医药大学，2014. [5]杨明.中药药剂学[M].上海：上海科学技术出版社，2006.
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备注/Memo
收稿日期：2016-07-03