GAO Yang,MU Xiang.Effect of Baicalein on LPS induced RIMECs Injury[J].HEILONGJIANG AGRICULTURAL SCIENCES,2018,(08):78-81.[doi:DOI:10.11942/j.issn1002-2767.2018.08.0078]
黄芩素对LPS诱导RIMECs损伤的作用效果
- Title:
- Effect of Baicalein on LPS induced RIMECs Injury
- 关键词:
- 肠黏膜微血管内皮细胞; 细菌脂多糖; 黄芩素
- 文献标志码:
- A
- 摘要:
- 为探究黄芩素的抗内毒素作用,利用MTT法,观察不同浓度黄芩素对细菌脂多糖(LPS)致肠黏膜微血管内皮细胞(RIMECs)损伤的作用效果。结果表明:LPS对RIMVECs增殖的抑制作用显著,而黄芩素对LPS诱导的RIMVECs损伤均均有一定的预防和治疗作用,细胞增殖率升高,且呈剂量依赖关系。
- Abstract:
- In order to explore the anti endotoxin effect of baicalein, in this study,MTT method was used to observed the effects of baicalein with different concentrations on injury of intestinal mucosal microvascular endothelial cells (RIMECs) induced by lipopolysaccharide (LPS).The results showed that baicalin had some preventive and therapeutic effects on injury of RIMVECs induced by LPS,and the cell proliferation rate was increased in a dose dependent manner.
参考文献/References:
[1]董小青,王金兰,崔颖,等.内毒素致病机理与抗内毒素药物研究概况[J].天津药学,2003(4):51-53.
备注/Memo
收稿日期:2018-03-26