[1]李敏,赵权,武晓林.鸡树条荚蒾抗炎活性研究[J].黑龙江农业科学,2012,(11):136-138.
　LI Min,ZHAO Quan,WU Xiao-lin.Study on the Anti-inflammatory Activity of the Water Extracts of Viburnum sargentii [J].HEILONGJIANG AGRICULTURAL SCIENCES,2012,(11):136-138.
点击复制

鸡树条荚蒾抗炎活性研究

《黑龙江农业科学》[ISSN:1002-2767/CN:23-1204/S] 卷: 期数: 2012年11 页码: 136-138 栏目: 出版日期: 2012-11-10
Title:
Study on the Anti-inflammatory Activity of the Water Extracts of Viburnum sargentii
文章编号:
1002-2767（2012）11-0136-03
作者:
李敏; 赵权; 武晓林
吉林农业科技学院 中药学院，吉林 吉林 132101
Author(s):
LI Min; ZHAO Quan; WU Xiao-lin
TraditionalChinese Medicine School of Jilin Agricultural Science and Technology College,Jilin,Jilin 132101
关键词:
鸡树条荚蒾; 茎枝; 抗炎活性
Keywords:
Viburnum sargentii; stem and branch; anti-inflammatory active
分类号:
K285
文献标志码:
A
摘要:
通过二甲苯致耳肿胀实验及毛细血管渗透性实验，研究了鸡树条荚蒾(Viburnum sargentii)抗炎活性。结果表明：与模型组比较，鸡树条荚蒾茎枝(15、20 g·kg-1组明显抑制小鼠耳廓肿胀，鸡树条荚蒾茎枝(10、15、20 g·kg-1)呈现量效关系；与模型组比较，鸡树条荚蒾茎枝(15、20 g·kg-1)组毛细血管通透性明显降低，鸡树条荚蒾茎枝(10 g·kg-1)也可以降低毛细血管通透性，鸡树条荚蒾茎枝(10、15、20 g·kg-1)之间有一定的差异，但量效关系不明显。因此，鸡树条荚蒾茎枝(15、20 g·kg-1)对二甲苯诱发小鼠急性炎症模型有效，鸡树条荚蒾10 g·kg-1无明显抗炎效果，说明中药的抗炎效果与剂量呈量效关系。
Abstract:
Through the trial that ear edema induced by dimethylbenzene in mice and permeability of capillaries,the anti-inflammatory effect of the water extracts of Viburnum sargentii’s stem and branch was investigated. The results showed that compared with the control,the water extracts of Viburnum sargentii’s stem and branch(15,20 g·kg-1)significantly reduced the swelling degree of tumefaction in mice,the water extracts of Viburnum sargentii’s stem and branch(10,15,20 g·kg-1)in a dose-effect relations;Compared with the control,the water extracts of Viburnum sargentii’s stem and branch(15,20 g·kg-1)significantly reduced the capillary permeability,the water extracts of Viburnum sargentii’s stem and branch(10 g·kg-1)could also reduce the capillary permeability.Among the water extracts of Viburnum sargentii’s stem and branch(10,15,20 g·kg-1)there were certain differences,but the difference was not significant,it indicated that the dose-effect relationship was not clear.Therefore,the water extracts of Viburnum sargentii’s stem and branch had anti-inflammatory effect at doses of(15,20 g·kg-1)in mice edema ear.The water extracts of Viburnum sargentii’s stem and branch 10 g·kg-1 had not obvious anti-inflammatory effect,description the antiinflammatory effects of traditional Chinese medicine in a dose-effect relationship.

参考文献/References:

[1] 周以良 . 黑龙江树木志 [M]. 哈尔滨 : 黑龙江科技出版社 ,1986 ： 145.

[2]朱有昌.东北药用植物[M].哈尔滨:黑龙江科技出版社,1989:106.

[3]北京医学院,北京中医学院.中草药成分化学[M].北京:人民卫生出版社,1980:240.

[4]张崇喜,李攀登,丛登立，等.GC-MS分析鸡树条荚蒾叶化学成分[J].资源开发与市场,2010,26(6):487.

[5]王宏钊,缪珊,孙纪元.α-亚麻酸药理研究进展[J].国际药学研究杂志,2007,34(4):254-255.

[6]王君明,王再勇,刘海，等.黄药子乙醇提取物抗炎活性研究[J].中医药报,2010(6):1127-1129.

[7]董长颖,吴俊波.蒲公英甾醇的提取及其抗炎活性研究[J].黑龙江畜牧兽医,2011(3):133-134.

[8]白峰,李瑾,王文魁.大叶桉叶挥发油的抗炎活性研究[J].中兽医医药杂志,2008(5):34-36.

备注/Memo

基金项目：吉林农业科技学院校内青年基金资助项目（2011207）

第一作者简介：李敏（1984-），女，吉林省大安市人，硕士，助教，从事天然药物化学与新药研发研究。E-mail：limin 1042004@163.com。

更新日期/Last Update: 2014-10-27