WANG Qianlin,XING Zhihua,ZHOU You.Research Progress on Chemical Constituents and Pharmacological Effects of Coptis chinensis[J].HEILONGJIANG AGRICULTURAL SCIENCES,2024,(03):102-109.[doi:10.11942/j.issn1002-2767.2024.03.0102]
黄连的化学成分及药理作用研究进展
- Title:
- Research Progress on Chemical Constituents and Pharmacological Effects of Coptis chinensis
- 文章编号:
- 17
- 文献标志码:
- A
- 摘要:
- 黄连是我国传统大宗中药,最早在《神农本草经》中被列为上品,到现在为止有两千多年的入药史。黄连是毛茛科多年生草本植物，是多种药方的构成基础。黄连物质基础繁多、药理作用复杂，且随着现代研究的不断深入，黄连新的化学成分不断被发掘，为进一步探索黄连的生产及功能价值，进而促进黄连的应用和开发。本文从黄连的生物学特性、化学成分、药理作用以及药用价值开发方面进行综述，发现黄连化学成分主要为生物碱、黄酮类、木脂素、酸性化合物、多糖类、甾体类及人体所必需的氨基酸、微量元素等，可通过不同的途径和作用靶点起到抑菌、降血糖、抗炎、抗氧化、抑制癌细胞增殖、缓解心肌缺血等药理作用。因此，应对黄连的化学成分进行系统性分离提取和生物活性测定，以及对相关机制加以研究。
- Abstract:
- Coptis chinensis is a traditional bulk Chinese medicine in China, which was first listed as the top grade in the Shennong Materia Medica Classic. Up to now, it has a history of more than 2 000 years as a medicine. C. chinensis is a perennial herb of the Ranunculaceae family, which is the basis of various medicinal prescriptions. C. chinensis has many material bases and complex pharmacological effects, with the deepening of modern research, new chemical components of C. chinensis have been continuously discovered, so as to further explore the production and functional value of C. chinensis and promote the application and development of C. chinensis. In this paper, the biological characteristics, chemical composition, pharmacological action and the development of medicinal value of C. chinensis were reviewed. It was found that the chemical composition of C. chinensis mainly consisted of alkaloids, flavonoids, lignans, acid compounds, polysaccharides, steroids, amino acids and trace elements necessary for human body. It can have pharmacological effects such as antibacterial, hypoglycemic, anti-inflammatory, antioxidant, inhibiting the proliferation of cancer cells and alleviating myocardial ischemia through different pathways and targets. Therefore, the chemical components of C. chinensis should be systematically separated and extracted, and the biological activity of C. chinensis should be further determined, and the related mechanisms should be studied.
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备注/Memo
收稿日期：2023-07-19