[1]李雯,党婷,曹燕,等.苦荞麦水提物对2型糖尿病小鼠的降血糖作用[J].黑龙江农业科学,2018,(03):58-61.[doi:10.11942/j.issn1002-2767.2018.03.0058]
　China Pharmaceutical University,Nanjing 98,China.LI Wen,DANG Ting,CAO Yan,FAN Yi-qiao[J].HEILONGJIANG AGRICULTURAL SCIENCES,2018,(03):58-61.[doi:10.11942/j.issn1002-2767.2018.03.0058]
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苦荞麦水提物对2型糖尿病小鼠的降血糖作用

《黑龙江农业科学》[ISSN:1002-2767/CN:23-1204/S] 卷: 期数: 2018年03期 页码: 58-61 栏目: 出版日期: 2018-03-10
Title:
LI Wen,DANG Ting,CAO Yan,FAN Yi-qiao
作者:
李雯; 党婷; 曹燕; 樊一桥
中国药科大学，江苏 南京 211198
Author(s):
China Pharmaceutical University; Nanjing 211198; China
China Pharmaceutical University,Nanjing 211198,China
关键词:
苦荞麦; 血糖; 链脲佐菌素; 2型糖尿病
Keywords:
Fagopyrum tartaricum;  blood sugar;  streptozotocin;  type 2 diabetes
DOI:
10.11942/j.issn1002-2767.2018.03.0058
文献标志码:
A
摘要:
为研究苦荞麦水提物对链脲佐菌素（streptozotocin，STZ）所致的2型糖尿病（type2 diabetes mellitus,DM2）小鼠的降血糖作用。将SPF级雄性ICR小鼠60只，按体重随机区分组法将其分为空白对照组和造模组，均用普通饲料喂养。除正常对照组外，其它50只小鼠经过注射STZ构建成为2型糖尿病小鼠模型，选择造模成功的小鼠将其随机平均分为模型组，二甲双胍组，苦荞麦低、中、高剂量组，灌胃给药后0、4、8、14 d测定小鼠血糖。在试验过程中，每天均对各组小鼠的进食量以及体重进行检测，并观察小鼠饮水量。结果表明：灌胃治疗14 d后，与模型对照组相比较，苦荞麦水提物各剂量组小鼠的体重明显增加（P＜0.01），而血糖显著下降（P＜0.01），其中苦荞麦水提物中剂量组小鼠的体重与血糖值变化最为显著。说明苦荞麦水提物具备一定的降低STZ致2型糖尿病小鼠血糖的作用，为预防和治疗糖尿病提供了一定的科学依据。
Abstract:
In order to study the hypoglycemic effect of Fagopyrum tartaricum water extracts on type 2 diabetes mellitus (DM2) mice induced by streptozotocin (STZ).Sixty male SPF ICR mice were randomly divided into blank control group and model group according to their weight,and all of them were fed with ordinary feed.Except the normal control group,the other 50 mice after injection of STZ into the construction of type 2 diabetic mice model,select the successful model of the mice which were randomly divided into model group,metformin group,Fagopyrum tartaricum was low,medium and high dose group.Blood sugar was measured after gavage treatment of 0,4,8,14 d.During the experiment,the intake and weight of the mice were measured every day,and the amount of drinking water in the mice was observed.The results showed that after gavage treatment of 14 d,compared with model group,the Fagopyrum tartaricum water extract of mice weight increased significantly in each dose group (P<0.01),while the blood glucose decreased significantly (P<0.01),and the changes in the the weight and blood of Fagopyrum tartaricum water extract dose group were the most significant.It showed that the Fagopyrum tartaricum water extract had a certain effect on reducing blood glucose in type 2 diabetic mice induced by STZ,and provided a scientific basis for preventing and treating diabetes.

参考文献/References:

[1]李伟,张红,殷松楼,等.不同剂量链脲佐菌素诱导SD大鼠糖尿病肾病模型的研究[J].徐州医学院学报,2006,26(1):52-55.
[2]张再超,叶希韵,徐敏华,等.葛根黄酮降血糖防治糖尿病并发症的实验研究[J].华东师范大学学报(自然科学版),2010,2010(2):77-81.
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备注/Memo

收稿日期：2018-01-06基金项目：中国药科大学药学基地科研训练及科研能力提高资助项目（J1310032）。第一作者简介：李雯（1997-），女，在读学士，从事药理学研究。E-mail：306430171@qq.com。通讯作者：樊一桥（1967-），女，硕士，副教授，从事药理学基础研究。E-mail:imyiqiao@163.com。

更新日期/Last Update: 2018-05-08