[1]孟凡丽.人参茎叶皂苷对醛糖还原酶的抑制作用[J].黑龙江农业科学,2017,(01):110-113.[doi:10.11942/j.issn1002-2767.2017.01.0110]
　MENG Fan-li.Study on Inhibitory Effect of Saponin of Ginseng Stems and Leavea on Aldose Reductase[J].HEILONGJIANG AGRICULTURAL SCIENCES,2017,(01):110-113.[doi:10.11942/j.issn1002-2767.2017.01.0110]
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人参茎叶皂苷对醛糖还原酶的抑制作用

《黑龙江农业科学》[ISSN:1002-2767/CN:23-1204/S] 卷: 期数: 2017年01期 页码: 110-113 栏目: 出版日期: 2017-01-10
Title:
Study on Inhibitory Effect of Saponin of Ginseng Stems and Leavea on Aldose Reductase
文章编号:
1002-2767（2017）01-0110-04
作者:
孟凡丽
辽宁农业职业技术学院 农学园艺系,辽宁 营口 115009
Author(s):
MENG Fan-li
Department of Agronomy and Horticulture,Liaoning Agricultural Technology College,Yingkou,Liaoning 115009
关键词:
人参茎叶; 人参皂苷; 醛糖还原酶抑制剂
Keywords:
ginseng stems and leaves;  ginsenosides;  aldose reductase inhibitor
分类号:
R284.1
DOI:
10.11942/j.issn1002-2767.2017.01.0110
文献标志码:
A
摘要:
以五年生人参茎叶为材料，提取总皂苷，用30%、50%、80%乙醇洗脱人参茎叶总皂苷获取不同种类和含量人参皂苷，测定不同浓度乙醇洗脱人参茎叶皂苷对醛糖还原酶（AR）抑制作用。结果表明：不同浓度乙醇洗脱人参茎叶皂对AR都有一定的抑制作用，其中对AR抑制作用最强的是80%乙醇洗脱人参茎叶皂苷对AR抑制作用超过阳性对照依帕司他（EPS）（P<0.01），30%乙醇洗脱人参茎叶皂苷和50%乙醇洗脱人参茎叶皂苷对AR抑制作用有一定的抑制，但没有超过EPS。醛糖还原酶抑制剂对糖尿病并发症，尤其是对糖尿病微血管并发症有很好的治疗效果。综上所述，人参茎叶提取总皂苷在糖尿病微血管并发症治疗方面有一定的应用价值。
Abstract:
The ginseng stems and leaves that had 5 years old as material,which were extracted total ginsenosides,which different types and contents of ginsenoside elutedwith 30%,50% and 80% ethanol,and different concentrations of ethanol elution ginseng stems and leaves ginsenoside on aldose reductase (AR) inhibition were determinated.The results showed that the elution of 80% ethanol had the strongest inhibitory effects on aldos reductase (AR),which was significantly stronger than that of the positive control of EPS（P<0.01）; the elutions of 30% and 50% ethanol both had certain inhibitory effects on AR,while that was not better than that of EPS.Aldose reductase inhibitor especially had a good therapeutic effect on diabetic microvascular complications.Above all,the total ginsenoside of ginseng stems and leaves had certain application value in the treatment of diabetic microvascular complications.

参考文献/References:

[1]孟凡丽,苏晓田,刘发贵，等.人参皂苷对醛糖还原酶的抑制作用[J].中国药理学通报,2011,27(6):827-830.
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备注/Memo

收稿日期：2016-12-03
作者简介：孟凡丽（1978-），女，山西省临汾市人，硕士，讲师，从事天然产物的开发与研究。E-mail:mengerr@163.com。

更新日期/Last Update: 2017-02-14