WU Jun-jing,QIAO Mu,PENG Xian-wen,et al.Molecular Mechanisms of Escaping Host Innate Immune Systems of PRRSV[J].HEILONGJIANG AGRICULTURAL SCIENCES,2013,(12):58-61.
PRRSV逃逸宿主天然免疫的分子机制
- Title:
- Molecular Mechanisms of Escaping Host Innate Immune Systems of PRRSV
- 文章编号:
- 1002-2767（2013）12-0058-04
- Keywords:
- PRRSV; innate immune; interferon
- 分类号:
- S852.65+9.6
- 文献标志码:
- A
- 摘要:
- 猪繁殖与呼吸综合症病毒（PRRSV）可破坏机体的天然免疫系统，导致猪的免疫抑制，进而导致继发感染或混合感染，为进一步研究PRRSV逃逸宿主天然免疫的分子机制，综述了PRRSV抑制Ⅰ型IFN的激活及其相关信号通路，逃逸宿主天然免疫系统的多种途径，从而避免PRRSV侵染，为PRRSV的防控提供分子基础。
- Abstract:
- Porcine Reproductive and Respiratory Syndrome(PRRS)could destroy innate immune system of pigs,made immune suppression and lead to secondary infection or mixed infection.In order to study the molecular mechanism of PRRSV escaping host innate immune,various pathways of inhibiting the activation of type I interferons and related signaling pathways to avoid the infection of PRRSV in pigs,so as to provide molecular basis for the prevention and control of PRRSV.
参考文献/References:
[1] Opriessnig T,Baker R B,Halbur P G.Use of an experimental model to test the efficacy of planned exposure to live porcine reproductive and respiratory syndrome virus[J].Clinical and Vaccine Immunology,2007,14(12):1572-1577.
[2]Draayer H A,Jungb ck C.Autogenous vaccines:determining product need and antigen selection,production and testing considerations[J].Developments in Biologicals,2004,117:43-47.
[3]Molina R M,Chittick W,Nelson E A,et al.Diagnostic performance of assays for the detection of anti-porcine reproductive and respiratory syndrome virus antibodies in serum and muscle transudate(“meat juice”)based on samples collected under experimental conditions[J].Journal of Veterinary Diagnostic Investigation,2008,20(6):735-743.
[4]李颖.细胞抗病毒天然免疫信号转导的调控机制[D].武汉：武汉大学,2011：13-28.
[5]刘梅,张丽丽,陈明.干扰素信号通路及其负调控因素的研究进展[J].医学综述,2009,15(19):2896-2898.
[6]Sadler A J,Williams B R G.Interferon-inducible antiviral effectors[J].Nature Reviews Immunology,2008,8(7):559-568.
[7]Génin P,Lin R,Hiscott J,et al.Differential regulation of human interferon A gene expression by interferon regulatory factors 3 and 7[J].Molecular and cellular biology,2009,29(12):3435-3450.
[8]O’Neill L A J,Bowie A G.Sensing and signaling in antiviral innate immunity[J].Current Biology,2010,20(7):328-333.
[9]Kong X F,Zhang X X,Gong Q M,et al.MxA induction may predict sustained virologic responses of chronic hepatitis B patients with IFN-α treatment[J].Journal of Interferon & Cytokine Research,2007,27(9):809-818. [10]Kawai T,Akira S.Innate immune recognition of viral infection[J].Nature immunology,2006,7(2):131-137. [11]孙岳平,肖家祁,邹嫣琼,等.RIG-Ⅰ与干扰素信号通路的关系[J].上海交通大学学报：医学版，2007,27(10):1210-1214.
[12]赵永刚,周艳春,李明才,等.TLR/MyD88信号通路与自身免疫性疾病[J].生命的化学,2008,28(4):457-460.
[13]O’Neill L A J,Bowie A G.The family of five:TIR-domain-containing adaptors in Toll-like receptor signalling[J].Nature Reviews Immunology,2007,7(5):353-364.
[14]Patel D,Nan Y,Shen M,et al.Porcine reproductive and respiratory syndrome virus inhibits type I interferon signaling by blocking STAT1/STAT2 nuclear transloca-tion[J].Journal of virology,2010,84(21):11045-11055.
[15]Costers S,Lefebvre D J,Delputte P L,et al.Porcine reproductive and respiratory syndrome virus modulates apoptosis during replication in alveolar macrophages[J].Archives of Virology,2008,153(8):1453-1465.
[16]于琳琳.猪繁殖与呼吸综合征病毒对两种猪致病性及其新型受体阳性细胞定位研究[D].泰安：山东农业大学,2012：32-44.
[17]Miller L C,Laegreid W W,Bono J L,et al.Interferon type I response in porcine reproductive and respiratory syndrome virus-infected MARC-145 cells[J].Archives of Virology,2004,149(12):2453-2463.
[18]Meier W A,Husmann R J,Schnitzlein W M,et al.Cytokines and synthetic double-stranded RNA augment the T helper 1 immune response of swine to porcine reproductive and respiratory syndrome virus[J].Veterinary Immunology and Immunopathology,2004,102(3):299-314.
[19]Brockmeier S L,Loving C L,Nelson E A,et al.The presence of alpha interferon at the time of infection alters the innate and adaptive immune responses to porcine reproductive and respiratory syndrome virus[J].Clinical and Vaccine Immunology,2012,19(4):508-514.
[20]Sun Y,Han M,Kim C,et al.Interplay between interferon-mediated innate immunity and porcine reproductive and respiratory syndrome virus[J].Viruses,2012,4(4):424-446.
[21]Wang D,Cao L,Xu Z,et al.MiR-125b Reduces Porcine Reproductive and Respiratory Syndrome Virus Replication by Negatively Regulating the NF-κB Pathway[J].PloS one,2013,8(2):55838.
[22]Kim O,Sun Y,Lai F W,et al.Modulation of type I interferon induction by porcine reproductive and respiratory syndrome virus and degradation of CREB-binding protein by non-structural protein 1 in MARC-145 and HeLa cells[J].Virology,2010,402(2):315-326.
[23]Song C,Krell P,Yoo D.Nonstructural protein 1 alpha subunit-based inhibition of NF-kappa B activation and suppression of interferon-beta production by porcine reproductive and respiratory syndrome virus[J].Virology,2010,407:268-280.
[24]Sun Y,Han M,Kim C,et al.Interplay between interferon-mediated innate immunity and porcine reproductive and respiratory syndrome virus[J].Viruses,2012,4(4):424-446.
[25]Ait-Ali T,Wilson A D,Westcott D G,et al.Innate immune responses to replication of porcine reproductive and respiratory syndrome virus in isolated Swine alveolar macrophages[J].Viral immunology,2007,20(1):105-118.
[26]肖犟.PRRSV对断奶仔猪生产性能和免疫力相关指标的影响[D].武汉：华中农业大学,2010：48-54.
[27]Lee S M,Schommer S K,Kleiboeker S B.Porcine reproductive and respiratory syndrome virus field isolates differ in in vitro interferon phenotypes[J].Veterinary immunology and immunopathology,2004,102(3):217-231.
[28]Ait-Ali T,Wilson A D,Carré W,et al.Host inhibits replication of European porcine reproductive and respiratory syndrome virus in macrophages by altering differential regulation of type-I interferon transcriptional response[J].Immunogenetics,2011,63(7):437-448.
[29]He D,Overend C,Ambrogio J,et al.Marked differences between MARC-145 cells and swine alveolar macrophages in IFNβ-induced activation of antiviral state against PRRSV[J].Veterinary immunology and immunopathology,2011,139(1):57-60.
相似文献/References:
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ZHOU Sheng,GAO Ge,SUN Dang,et al.The Gene Clone,Prokaryotic Expression and AntigenEpitopes Prediction of the Cysteine Domain ofNonstructural Protein 2 of PRRSV[J].HEILONGJIANG AGRICULTURAL SCIENCES,2012,(12):25.
备注/Memo
收稿日期：2013-08-08
基金项目：湖北省农业科学院青年基金资助项目（2013NKYJJ11）；动物胚胎工程及分子育种湖北省重点实验室资助项目（2013ZD101）
第一作者简介：吴俊静（1984-），女，湖北省武汉市人，博士，助理研究员，从事猪遗传育种研究。E-mail：jeanne1106@126.com。
通讯作者：梅书棋（1971-），男，湖北省武汉市人，硕士，研究员，从事猪遗传育种、猪新品系及配套选育等方面的研究。E-mail:msqlfe@163.com。