QIN Zhen,XU Lai-xiang.The Study Progress of Animal Defensins[J].HEILONGJIANG AGRICULTURAL SCIENCES,2007,(06):102-104.[doi:10.11942/j.issn1002-2767.2007.06.0102]
动物防御素研究进展
- Title:
- The Study Progress of Animal Defensins
- 文章编号:
- 1002 -2767(2007)06-0102-03
- 关键词:
- 曲阜师范大学生命科学院; 曲阜273165
- 分类号:
- S816 .73
- 文献标志码:
- A
- 摘要:
- 防御素(defensin)是一族具有广谱抗微生物和细胞毒活性的多肽, 是天然免疫的重要介质, 属内源性抗生素肽(endo genous antibiotic peptides)家族。介绍了动物防御素的分布、结构、表达、作用机理等方面的内容。
- Abstract:
- Defensin is a type of catio nic antimicrobial pe ptides , containing abundant a rgininesand intramo lecular disulfide bo nds formed with cy steins .They belo ng to endog eno us antibio tic peptides family . Defensins have broad-spectrum and hig hly efficient antimicro bial activity .This a rticle briefly intr oduced the research advance of defensins in distribution , molecula r characteristics and functio nal mechanism .
参考文献/References:
[ 1] Mak P , Woj cik K .Isolat ion , antimicrobial act ivit ies and primaryst ructu res of hamst er neut rophil def ensins [ J] .Inf ect Im mun , 1996, 64 :4444-4447 .
[ 2] Bensch K W, Raida M , Magert H G , et al.hBD-1 :a novelβ - def ensin f rom human plasma [ J] .FEBS Lett , 1995 , 17 :331-336 .
[ 3] Zhao C , Wang I .Wides pread expression of bet a def en sin hBD -1 in hum an secret ory glands and epithelial cells[ J] .FEBS Let t , 1996 , 396(2 ~ 3):319-323 .
[ 4] Harder J , Bart els J , Ch ri st ophers HG , et al.A peptide ant ibiot ic f rom hum an skin [ J] .Nature , 1997, 387 (6636):861-865 .
[ 5] Jia H P , S chu tt e B C , Sch udy A , et al .Discovery of new humanβ - def ensins u sing a genomics -based approach [ J] .Gene, 2001 , 263(122):211-218.
[ 6] Bal s R, Goldman M J , Wi lson J M .Mouse β -def ensin is a S alt -sen sit ive Ant imicrobi al Pep tide Present in Epi th elia of th e Lu ng and Urogen tial Tract [ J] .Inf ect Immun , 1998 , 63 (3):1225-1232 .
[ 7] Kevin L P , Meli ssa H B , Robert E W.Recombin ant DNA Procedu res f or Producing Small Ant imicrobial Cat ionic Peptides in Bact eri a[ J] .Gene, 1993 , 134(1):7-13.
[ 8] Liu L D, Wang L N , Ji a H P , et al.S t rucru re and m appin gof th e humanβ -def en sin HBD -2 gene and i ts expression at sit e of inf lam mation[ J] .Gen e, 1998 , 222 :237-239 .
[ 9] Zhang G L , H iraiw a H , Yasu e H , et al.Cloning and charac2 terizati on of the gene f or a new epithelialβ -def ensin[ J] . JBio Ch em , 1999 , 274 :24-31 .
[ 10] Garcia C , Krause A , Sandra S , et al.H uman 4 :a novel indu cible pept ide w ith a specific salt2sensit ive s pectrum of ant imi crobial activit y[ J] .J FASEB , 2001 , 15 :1819-1823 .
[ 11] H arder J , Bartels J , Chris tip hers H G , et al.Isolation and ch aract eri zation of humanβ -defensin -3 , a n ovel hum an inducib le peptide antibi oti c [ J] .J Bio C hem , 2001 , 276 (8): 5707-5713 .
[ 12] Lich en stein A K , Ganz T , S elet ed M E , et al .Def ensins [ J] . Cell Immunol , 1998 , 114 :104-116 .
[ 13] Diamond G, John P, Rus sel , et al.Inducible expressi on of an antibioti c pept ide gene in lipopolysaccharide2chall enged t racheal epithelial cell s[ J] .J FASEB , 1996 , 93 :5156-5160 .
[ 14] Lavashina E A , Ohresser S , Lemai tre B , et al.Tw o dis tin ct pathw ays can cont rol exp ressi on of the gene encoding the Drosophi la antimicrobial peptide met chnikowin [ J] .J Mol Bi ol , 1998 , 278 :515-519 .
[ 15] H uan g G T , Zhang H B , Kim D , et al.A model f or an timicrbi al gene therapy :demonst rati on of hum an b et a2def ensin 2 antimicrobial act ivi ti es in vivo [ J] .Hum Gene T her , 2002 , 13 (17):2017-2025 .
[ 16] Valore E V , Park C H , Qu ayle A J , et al .Hum an β -Def ensin -1 :Antimicrobial Pept ide of Urogeni tal Ti ssues [ J] .J Clin Inest , 1998 , 101(5):1633-1642 .
[ 17] Ganz T .Versati le def en sins [ J] .Sci ence , 2002 , 298 (5595) : 977-979 .
[ 18] Yang D, C hertov O , Bykovsk aia S N , et al.β -def ensin : Linking innate and adapt ive immu ni ty through dendrit ic and T cell CCR6[ J] .S cience, 1999 , 286 :525-528 .
[ 19] Zhang L , YU W , H e T , et al.Cont ribu tion of human alpha - defensin1 , 2 and 3 t o th e ant iH IV -1 act ivit y of CD8 anti vi ral f act or[ J] .S cien ce, 2002 , 298 :995-1000 .
备注/Memo
收稿日期:2007 -07 -02
基金项目:山东省教育厅科技计划项目(重点)(J06I04);2006 年济宁市重大科技专项(济科技[ 2006] 011);曲阜师范大学硕士科研启动金资助项目
第一作者简介:秦桢(1979 -), 男, 山东诸城人, 硕士, 讲师, 主要从事遗传学的教学与研究。E -m ail :qin zhen2001 @163 .com 。