YUAN HONGmei,ZHANG LI-xia,ZHANG HONG,et al.Progress of Research on SOX9 Gene[J].HEILONGJIANG AGRICULTURAL SCIENCES,2007,(03):124-127.[doi:10.11942/j.issn1002-2767.2007.03.0124]
SOX9基因的研究进展
- Title:
- Progress of Research on SOX9 Gene
- 文章编号:
- 1002- 2767(2007)03-124-04
- Keywords:
- SOX9; HMG box; sex determination; cartilage formation
- 分类号:
- Q78
- 文献标志码:
- A
- 摘要:
- SOX9基因是SOX基因家族的一个重要成员，在哺乳动物性别决定和软骨生成中起着关键的调控作用。从基因的结构、表达、生化特性、蛋白之间的作用及功能等几方面阐述了SOX9基因的研究进展
- Abstract:
- SOX9 gene is an important member in SOX gene family. It plays an important role in sex-de- termination and cartilage formation in mammals. TEus paper outlinedthe progress of research on SOX9 from a few aspects: the structure, expression, biochemical characteristics, proteins interaction and functions
参考文献/References:
[1]常重杰，杜启艳，邵红伟，Sox基因家族研究的新进展[J].遗 传，2002,24(4):470-476.
[2] BellDM, Leung KK, Wheatley SC, et al. S()X9 directly regu- lates the type-ll collagen gene[J]. Nat Genet,1997, (16); 174-178.
[3] Koopman,P.Sry and SOX9: mammalian testis-determining genes[J]. Cell Mol Life Sci. ,1999,(55):839-856.
[4] Foster JW, Graves JA. An SRY- related sequence on the Marsupial X chromosomea Implicationsfor the evolution ofthe mammalian testis-determining gene[J]. Proc Natl Acad Sci USA, 1994,91(5)11927-1931.
[5] Wagner T, Wirth J.Meyer J,et aL Autosomal sex reversal and campomelic dysplasia are caused by mutations.n and a round the SRY-related gene SOX9[J]. Cell, 1994, 79(6): 1111-1120.
[6]王毅．SOX9基因与性别决定的关系[J].生命的化学，2000. 20 (2)170-71.
[7] Jennifer A, Marsshll G. Evolution of the mammalian Y chro- mosome and sex-determining genes [J].J Exp Zool, 1998, 2811472-81.
[8] Meyer J,S dbeck P,Held M,et aL Mutational analysis of the SOX9 gene in campomelic dysplasia and autosomal sex rever- sal: lack of genotype/phenotype correlations[J]. Hum. Mol. Genet, 1997, 6(1) ;91-98.
[9] Ng, LJ,Wheatley S,Muscat GEO,et al. SOX9 binds DNA,ac- tivates transcriptionand coexpresses with type Hcollagen dur- ing chondrogenesis in the mouse[J]. Dev Biol,1997, 183(1): 108-121.
[10] Bell DM, Leung KK, Wheatley, SC, et al. SOX9 directly reg- ulates the type-ll collagen gene[J]. Nature Genet, 1997, 16 (2)；174-178.
[11]秦宏敏，许铁，姚爱明，等．SOX9基因与软骨组织的研究进展 [J].中华实验外科杂志．2006,23(2)。255-256.
[12] Kenji Ohe.A direct role of SRY and SOX proteins in pre- mRNA splicing[l]. PANS, 2002,99(3):1146-1151.
备注/Memo
收稿日期：2007-02-02
第一作者简介：袁红梅(1979-)．女，黑龙江省齐齐啥尔市人，硕士，助教，从事遗传学研究．Tel: 0459 - 5026060;E- mail: yuanhm1979@ 163．com。