[1]宋冬雪,韩莹徽,林立青,等.紫花苜蓿素化学成分中Coumestan结构母核的全合成研究进展[J].黑龙江农业科学,2021,(11):113-120.[doi:10.11942/j.issn1002-2767.2021.11.0113]
　ONG Dong-xue,HAN Ying-hui,LIN Li-qing,et al.Progress in Total Synthesis of Coumestan Structure Parent Nucleus from Alfalfa Compounds[J].HEILONGJIANG AGRICULTURAL SCIENCES,2021,(11):113-120.[doi:10.11942/j.issn1002-2767.2021.11.0113]
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紫花苜蓿素化学成分中Coumestan结构母核的全合成研究进展

《黑龙江农业科学》[ISSN:1002-2767/CN:23-1204/S] 卷: 期数: 2021年11 页码: 113-120 栏目: 出版日期: 2021-11-10
Title:
Progress in Total Synthesis of Coumestan Structure Parent Nucleus from Alfalfa Compounds
作者:
宋冬雪; 韩莹徽; 林立青; 许颖; 綦峥; 刘颖杰
哈尔滨商业大学 药物工程技术研究中心，黑龙江 哈尔滨 150076
Author(s):
ONG Dong-xue; HAN Ying-hui; LIN Li-qing; XU Ying; QI Zheng; LIU Ying-jie
Engineering Research Center for Medicine,Harbin University of Commerce,Harbin 150076,China
关键词:
Coumestan类化合物; 蟛蜞菊内酯; 香豆素; 苯并呋喃; 催化剂
Keywords:
Coumestanlike compounds;  chrysanthemum;  coumarin;  benzofuran;  catalyst
DOI:
10.11942/j.issn1002-2767.2021.11.0113
文献标志码:
A
摘要:
Coumestan是主要存在于豆科、菊科等植物中的一类天然产物。具有抗癌、抗菌、抗氧化、保肝、治疗骨质疏松、止血、免疫调节、解蛇毒、植物保护等广泛的药理活性。鉴于Coumestan类化合物的各项药理活性，其合成途径的研究成为关键。本文采用查阅国内外文献的方法，对Coumestan类化合物的研究现状进行分析，基于Coumestan类化合物的四环基本骨架结构，将此类化合物的合成路径按照不同环进行了归类，分别是在AB环的基础上合成CD环、在CD环的基础上合成AB环，以及除此之外的依赖电化学和光化学等方法进行的合成。通过对Coumestan类化合物合成路径的总结，梳理出此类化合物合成路线的完善部分以及试验的空白部分。
Abstract:
Coumestans compounds have a wide range of pharmacological activities such as anticancer,antioxidation,liver protection,osteoporosis,immune regulation,and venom.In view of the various pharmacological activities of coumestans compounds,the synthetic route has become the key to research.In this paper,the research status of Coumestan compounds was analyzed by consulting the literature at home and abroad.Based on the four ring basic skeleton structure of Coumestan compounds,the synthesis paths of these compounds were classified according to different rings,namely,CD ring based on AB ring and AB ring based on CD ring.In addition,the synthesis depends on electrochemical and photochemical methods.By summarizing the synthesis path of Coumestan compounds,the perfect part of the synthesis path and the blank part of the experiment were sorted out.

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备注/Memo

收稿日期：2021-09-07

基金项目：黑龙江省自然科学基金优秀青年项目（YQ2019B004）。
第一作者：宋冬雪（1984-），女，硕士，助理研究员，从事天然产物抗肿瘤作用研究。E-mail:S195844330@163.com。
通信作者：刘颖杰（1985-），女，博士，助理研究员，从事天然产物结构修饰及药物分子设计研究。E-mail:lyj850527@163.com。

更新日期/Last Update: 2021-12-07