CAI Ming-you,LIU Hong-zhang,LIU Shu-ying.Research Progress on Pharmacological Effects of Phellodendron amurens[J].HEILONGJIANG AGRICULTURAL SCIENCES,2013,(07):152-157.
黄檗药理作用的研究进展
- Title:
- Research Progress on Pharmacological Effects of Phellodendron amurens
- 文章编号:
- 1002-2767(2013)07-0152-06
- 分类号:
- Q949.752.7;R285
- 文献标志码:
- A
- 摘要:
- 为了更好地保护黄檗的野生资源,介绍了黄檗的化学成分,归纳总结了黄檗的药理作用,包括抑菌作用、对血管的作用、对免疫系统的作用、抗癌作用、抗肿瘤作用、降血糖作用、溃疡性结肠炎、抗氧化作用、治疗前列腺的作用、抗病毒作用、抗痛风作用、对皮肤病的作用、抗炎作用、对神经系统的作用等多方面有着良好的开发前景。
- Abstract:
- In order to protect wild resources of Phellodendron amurense better,chemical component of Phellodendron amurense was introduced,the pharmacological effects of Phellodendron amurens were summarized,including bacteriostatic action,the effect on the blood vessels,the role of the immune system,anti-cancer effects,anti-tumor effect,hypoglycemic effect,ulcerative colitis,anti-oxidation,treatment of prostate,anti-viral activity,anti-gout role,anti-dermatology role,anti-inflammatory effects,the role of the nervous system and so on.So it has good prospects for development.
参考文献/References:
[1]秦彦杰,王洋,阎秀峰.中国黄檗资源现状及可持续利用对策[J].中草药,2006,37(7):1104-1107.
[2]胡俊青,胡晓.黄柏化学成分和药理作用的现代研究[J].当代医学,2009,15(7):139-141.
[3]Chen Meng-Li,Xian Yan-Fang,Siu-Po Ip,et al.Chemical and biological differentiation of cortex phellodendri chinensis and cortex Phellodendri amurensis[J].Planta Medica,2010,76(14):1530-1535.
[4]杨保成.关黄柏资源枯竭需求热价攀升——东北关于黄柏走势浅析[J].中国现代中药,2008,10(5):43-44.
[5]梁莹.黄柏抑菌效果的实验研究[J].现代医药卫生,2005,21(20):2746-2747.
[6]刘春平,赵淑肖,陈强,等.盐酸小檗碱抗5种皮肤癣菌实验观察[J].临床皮肤科杂志,2005,34(1):29.
[7]林海,龚又明,邓广海.黄柏及其炮制品水提物体内、外抑菌作用研究[J].中国药房,2012,23(31):2900-2902.
[8]陈蕾,邸大琳.黄柏体外抑菌作用研究[J].时珍国医国药,2006,17(5):759-760.
[9]Wang Wei,Zu Yuangang,Fu Yujie,et al.In vitro antioxidant,antimicrobial and anti-herpes simplex virus type 1 activity of Phellodendron amurense Rupr.from China[J].The American Journal of Chinese Medicine,2009,3(7):195-203.
[10]舒珍菊,赖洁.黄柏湿敷治疗透析患者穿刺血管硬化的效果观察[J].吉林医学,2011,32(2):269-270.
[11]王德全,胡俊英.黄柏胶囊抗炎疗效临床分析[J].中华实用中西医杂志,2004,17(6):839.
[12]吕燕宁,邱全瑛.小檗碱对小鼠DTH及其体内几种细胞因子的影响[J].中医中药与免疫,2000(3):139.
[13]陈韩英,刘丽梅,许剑琴,等.四种黄柏生物碱对热应激后小鼠脾淋巴细胞体外增殖以及IFN2γ和IL24水平的影响[J].中国兽医科学,2007,37(7):602-605.
[14]Hiroshi Mori,Masahiro Fuchigami,Naoki Inoue,et al.Principle of the bark of Phellodendron amurense to suppress the cellular immune response:effect of phellodendrine on cellular and humoral immune responses[J].Planta Medica,1995,61(1):45-49.
[15]Yan Hui,Sun Xiaodi,Sun Shiguang,et al.Anti-ultraviolet radiation effects of Coptis chinensis and Phellodendron amurense glycans by immunomodulating and inhibiting oxidative injury[J].International Journal of Biological Macromolecules,2011,48:720-725.
[16]张丽云.柴胡、苦参、大黄、黄柏对人宫颈癌细胞抑制效果的研究[D].北京:中国农业科学院,2011:42.
[17]杨菁,林菁.盐酸小檗碱对小鼠移植性肿瘤的抑制作用[J]-.药物研究,2009,18(1):4-5.
[18]许成山,周克元.小檗碱抗肿瘤作用研究进展[J].现代肿瘤医学,2009,17(1):147-149.
[19]Anis KV,Rajeshkum ar NV,Kuttan R.Inhibition of chemical carcinogenesis by berberine in ratsandmice[J].Pharmaco,2001,53(5):763-768.
[20]赵民,迟华基,牟文丽,等.盐酸小檗碱抗假丝酵母菌及抗肿瘤活性研究[J].实用口腔医学杂志,2009,25(2):193-196.
[21]Kumar Addanki P,Shylesh Bhaskaran,Manonmani Ganapathy,et al.Akt/cAMP-responsive element binding protein/cyclin D1 network:A novel target for prostate cancer inhibition in transgenic adenocarcinoma of mouse prostate model mediated by nexrutine,a Phellodendron amurense Bark extract[J].Clin.Cancer Res.,2007,13:2784.
[22]Garcia,Nicole,Bhaskaran,et al.Akt-and CREB-mediated prostate cancer cell proliferation inhibition by Nexrutine,a Phellodendron amurense extract[J].Neoplasia,2006,8(6)-:523-533.
[23]Robson Craig H,Manonmani Ganapathy,Gregory P Swanson,et al.Phellodendron amurense Bark extract enhances radiosensitivity by inhibition of NF-κB in transgenic adenocarcinoma of mouse prostate model and human prostate cancer cells[J].The Journal of Urology,2009,181(4)-:479.
[24]Kumar A P,Graham H,Robson C,et al.Natural products:potential for developing Phellodendron amurense Bark extract for prostate cancer management[J].Mini Reviews in Medicinal Chemistry,2010,10(5):388-397.
[25]James Michael A,Fu Huijing,Liu Yan,et al.Dietary administration of berberine or Phellodendron amurense extract inhibits cell cycle progression and lung tumorigen-esis[J]-.Molecular Carcinogenesis,2011,50(1):1-7.
[26]Min Yong Deuk,Kwon Hak Cheol,Yang Min Cheol,et al.Isolation of limonoids and alkaloids from Phellodendron amurense and their multidrug resistance(MDR)reversal activity[J].Archives of Pharmacal Research,2007,30(1):58-63.
[27]Kim Sungjin,Kim You Young,Kwang Ho Ko,et al.Butanol extract of 1∶1 mixture of Phellodendron cortex and Aralia cortex stimulates PI3-kinase and ERK2 with increase of glycogen levels in HepG2 cells[J].Phytotherapy Research Volume,1998,12(4):255-260.
[28]Lee Youngmi,Kim Harriet,Choi Hee-Sook,et al.Effects of water extract of 1∶1 mixture of Phellodendron cortex and Aralia cortex on polyol pathway and oxidative damage in lenses of diabetic rats[J].Phytotherapy Research,1999,13(7):555-560.
[29]Lee YoungMi,Kim Harriet,Hong EunKyung,et al.Water extract of 1∶1 mixture of Phellodendron cortex and Aralia cortex has inhibitory effects on oxidative stress in kidney of diabetic rats[J].Journal of Ethnopharmacology,2000,73(3):429-436.
[30]Julius Oben,Ebangha Enonchong,Shil Kothari,et al.Phellodendron and Citrusextracts benefit joint health in osteoarthritis patients:a pilot,double-blind,placebo-controlled study[J].Nutrition Journal,2009,8:38.
[31]吴颖.复方黄柏液结肠水疗辅助治疗溃疡性结肠炎的护理[J]-.现代临床护理,2011,10(4):27.
[32]Chiu Chih-Yang,LI ChiaYing,Chiu ChaoChen,et al.Constituents of leaves of Phellodendron japonicum MAXIM.and their antioxidant activity[J].Chemical and Pharmaceutical Bulletin,2005,53(9):1118-1121.
[33]Xu Yuanhao,Sabatino Ventura.Extracts of bark from the traditional Chinese herb Phellodendron amurense inhibit contractility of the isolated rat prostate gland[J].Journal of Ethnopharmacology,2010,127(1):196-199.
[34]Hye-Young Kima,Hyun-Soo Shin,Hyun Park,et al.In vitro inhibition of coronavirus replications by the traditionally used medicinal herbal extracts,Cimicifuga rhizoma,Meliae cortex,Coptidis rhizoma and Phellodendron cortex[J].Journal of Clinical Virology,2008,41:122-128.
[35]杨-澄,朱继孝,王颖,等.盐制对黄柏抗痛风作用的影响[J]-.中国中药杂志,2005,30(2):145.
[36]毛燕欣,庄洁,赵志刚.黄柏在皮肤科的临床应用与药理研究[J].中国中医药现代远程教育,2007,5(5):34-36. [37]Kima JooHee,Huhb JeongEun,Yong-Hyeon Baekc,et al.Effect of Phellodendron amurense in protecting human osteoarthritic cartilage and chondrocytes[J].Journal of Ethnopharmacology,2011,134:234-242.
[38]Huh J,Baek Y H,Lee J D,et al.Phellodendron amurense regulate the levels of matrix metalloproteinases,proinflammatory cytokines and signaling of the mltogen activated protein kinase(MAPK)pathway in human osteoarticular cartilage and chondrocytes[J].Osteoarthritis and Cartilage,2011,19(1):230.
[39]Eun Kyung Park,Hae In Rhee,Hye Sook Jung,et al.Antiinflammatory effects of a combined herbal prepara-tion(RAH13)-of Phellodendron amurense and Coptis chinensis in animal models of inflammation[J].Phytotherapy Research,August,2007,21(8):746-750.
[40]Xian YanFang,Mao QingQiu,Ip SiuPo,et al.Comparison on the anti-inflammatory effect of Cortex Phellodendri chinensis and Cortex Phellodendri amurensis in 12-O-tetradecanoyl-phorbol-13-acetate-induced ear edema in mice[J]-.Journal of Ethnopharmacology,2011,137(3):1425-1430.
[41]Mao YanFei,Li YongQi,Zong Lin,et al.Methanol extract of Phellodendri cortex alleviates lipopolysaccharide-induced acute airway inflammation in mice[J].Immunopharmacology and Immunotoxicology,2010,32(1):110-115.
[42]We Seo Ryang,Eun Ok Jeong,Yun Hyung Koog,et al.Effects of nutraceuticals on knee osteoarthritis:Systematic review[J].African Journal of Biotechnology,2012,11(12):2814-2821.
[43]Bombi Lee,Bongjun Sur,Insop Shim,et al.Phellodendron amurense and its major alkaloid compound,berberine ameliorates scopolamine-induced neuronal impairment and memory dysfunction in rats[J].Korean J.Physiol Pharmacol.,2012,16(2):79-89.
[44]李峰,贾彦竹.黄柏的临床药理作用[J].中医药临床杂志,2004,16(2):191.
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备注/Memo
收稿日期:2013-03-19
第一作者简介:蔡明友(1986-),男,吉林省白山市人,在读硕士,从事长白山植物资源研究。E-mail:huntercmy@yeah.net。